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While the entire healthcare industry adapts to changes induced by the COVID-19 pandemic, the global medical devices industry is undergoing major transformations in terms of business models, technological adoptions, care delivery approaches, and across other areas. Supply chain challenges are very likely to continue all throughout the year, further impacting availability of raw materials, as well as finished devices, further also driving inflation up. The global crisis of healthcare workforce shortages (compounding the issue of medical device uptake), which are further exacerbated by workforce burnouts, COVID19 infections, healthcare staff vaccine mandates, ‘Great Resignation’ and sky-rocketing salaries for nurses, as well as ‘Great Retirement’, are expected to continue in 2022. However, there will be a rising demand for bio-surveillance devices for infection prevention in hospitals and other healthcare facilities, along with increasing demand of innovative solutions for digital operating room management and efficiency. As higher acuity cases are gradually shifting towards ASCs, medtech OEMs are increasingly redesigning their device portfolios to suit the customized needs of this care provider type. On the other hand, women’s health, promises to be another high growth segment as the surge in women entrepreneurs, emergence of more women-led startups, women’s health initiatives by the US FDA and other associations are driving the femtech industry with innovative solutions to address long-standing women health and hygiene issues.